Federica Eduati

ESVP-ECVP Congress
f.eduati@tue.nl
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Dr. Federica Eduati is an Associate Professor in the Department of Biomedical Engineering at Eindhoven University of Technology (TU/e), where she leads the Systems Biology for Oncology group. Her research focuses on understanding tumors as complex ecosystems by developing interpretable computational models that integrate biological knowledge with diverse experimental data.
Her group combines mechanistic modeling and machine learning to investigate cancer progression and treatment response across scales—from intracellular signaling to multicellular interactions within the tumor microenvironment. A key focus is on integrating multimodal data, including transcriptomics, spatial omics, radiology, and digital pathology, to study how spatial tissue architecture shapes tumor behavior and therapeutic outcomes. By linking molecular data with imaging-derived features, her team aims to uncover actionable biomarkers and the mechanistic basis of treatment resistance and response.
She has pioneered the use of logic-based dynamic models of intracellular signaling in tumor cells to personalize combination therapies based on patient-specific perturbation data. Her group also works on agent-based models to simulate spatially constrained tumor growth. These models allow for explicit representation of interactions between different cell types—such as cancer, immune, and stromal cells—within the tumor microenvironment, offering insight into how local cellular composition and spatial organization drive tumor development and influence treatment outcomes. Her group’s systems-level modeling approach earned top performance in the DREAM Anti-PD1 Response Prediction challenge, demonstrating the value of interpretable computational models in predicting immunotherapy outcomes.
Committed to translational impact, Dr. Eduati co-founded the TheraME! consortium, which focuses on advancing personalized cancer treatment through microfluidic technologies for drug screening on patient biopsies. This effort contributed to the founding of the Swiss startup TheraME! AG. Dr. Eduati’s group also collaborate actively with the Catharina Hospital to support clinical adoption of liquid biopsy data for lung cancer diagnosis and treatment monitoring.
She holds a PhD from the University of Padova and conducted her postdoctoral research at the European Molecular Biology Laboratory, working across EMBL-EBI in Cambridge and EMBL Heidelberg. Her work has been published in leading journals such as Nature Biotechnology, Nature Communications, Molecular Systems Biology, and Cancer Research, and contributes to advancing biological understanding, enabling technological innovation, and supporting clinically relevant applications.