IATP Symposium


(seperate registration is required)


New Approach Methodologies (NAMs) for Neurotoxicity Assessment and

Regulatory Perspectives


New approach methodologies (NAMs) are non-animal test methods, technologies, strategies, approaches, or any combination thereof, that can be used to provide information on chemical hazard and risk assessment in lieu of complex laboratory animal studies. NAMs include in silico, in chemico, in vitro, and ex vivo approaches that reduce, refine, or replace (3R) the use of animals. The 2024 International Academy of Toxicologic Pathology (IATP) Satellite Symposium is poised to provide a background and perspectives on the use and implementation of specific NAMs. These include: 

  • Background, regulatory case studies, National Institutes of Health (NIH) Screening Program.
  • Perspectives on NAMs in Developmental (DNT) and Adult Neurotoxicity (ANT).
  • Mapping cellular outcomes from in vitro NAMs to neuropathological findings in animals/humans.
  • Larval zebrafish as an in vivo alternative model for assessing drug seizure liability using behavioral and functional brain imaging endpoints.
  • Assessment of chronic toxicity using NAMs (Parkinson’s Disease).


Room: Aula 13

09.00-09.10 | Welcome and Introduction | IATP Education Committee

09.10-09.55 | Scientific Efforts for Gaining Regulatory Confidence in NAMs for Neurotoxicity | Dr. Ellen Fritsche, MD.

09.55-10.40 | Current State of Developmental Neurotoxicity (DNT) Assessment Using New Approach Methodologies (NAMs) | Dr. Helena Hogberg-Durdock, PhD.

10.40-11.10 | Coffee Break

11.10-11.50 | Larval zebrafish as an Alternative in vivo Model for Assessing Seizure Liability: from Behaviour through to Functional Brain Imaging | Dr. Matthew Winter, PhD.

11.50-12.30 | Assessment of Chronic Neurotoxicity using NAMs | Dr. Andrea Terron, DVM, FRCPath.

12.30-12.55 | Panel Discussion

12.55-13.00 | Closing Remarks | IATP Education Committee

13.00-14.00 | Lunch & Exhibition