Thursday 1 October

Location: Room S3

Topic 3: Advancements in Genetically Engineered Animal Models for Nonclinical Safety
08:15 - 08:30 | TBC
08:30 - 09:15 | Introductory talk on genetically engineered animal models - Roland Rad
09:15 - 09:50 | Genetically engineered mouse models in preclinical research: Challenges and considerations for pathologists - Sebastien Monette
09:50 - 10:10 | MALT-1 deficiency models, not every KO methods is giving the same phenotype - Alessandro Piaia

10:10 - 10:55 | Morning Coffee Break | Room S4 - Exhibition

10:55 - 11:25 | Neurodegenerative, musculoskeletal, and patient-derived xenografts GEM models - Alys Bradley
11:25 - 11:50 | Humanized Mouse Models for Cell and Gene Therapy Safety: Power, Pitfalls, and the Pathologist’s Perspective - Giovanni Pelligrini
11:50 - 12:15 | Humanized Mouse Model for Nonclinical Safety Assessment of an Immunotherapeutic Monoclonal Antibody: Challenges and Lessons Learned. - Deven Dandekar
12:15 - 12:45 | Round table: transgenic rodent models, where are we? What's next? What are the challenges? - All speakers

12:45 - 13:45 | Lunch Break | Room S4 - Exhibition

13:45 - 14:15 | TBC
14:15 - 15:15 | AGA

15:15 - 15:45 | Afternoon Coffee Break | Room S4 - Exhibition

15:45 - 16:15 | Award ceremony
16:16 - 17:00 | Opportunities for using genetically engineered minipig in safety assessment: is there a path to replace non human primates? OR Opportunities for using genetically engineered minipig in drug development: the NHPig consortium and beyond - Tatiana Flisikowska
17:00 - 17:45 | Genome-editing in rabbits and non-human primates using pluripotent stem cells, germ line chimeras, and nuclear transfer cloning - Pierre Savatier